19815 Bay Branch Rd
Andalusia, Alabama 36420
(334) 222-2525



Facebook    

 

SCAMHC is an approved Mental Health site for the National Health Service Corps Loan Repayment program.  Find out the program details and see if you qualify by visiting: http://nhsc.hrsa.gov/

SCAMHC is an Equal Opportunity Provider and Employer and maintains a Drug-Free Workplace


powered by centersite dot net
Health Sciences
Resources
Basic InformationLatest News
Scientists Spot Genes Behind Skin ColorScientists Support Genome Editing to Prevent DiseaseBrain Disconnects Spotted in Parkinson's Patients With Visual HallucinationsCoffee Doesn't Help Parkinson's Motor DisordersCan Babies Help Heart Patients?Scientists Spot Marker for CTE in Living Football PlayersNerve Stimulation Pulls Patient From 15-Year Vegetative StateWhy Your Nose May Be Key to Parkinson's RiskEvolution Not Over for HumansBrain Scans Offer Clues to Why Some Teens Pile on PoundsNew Clues to Why Yawns Are ContagiousNew Hope From Old Drugs in Fight Against Parkinson'sFirst Gene Therapy Approved in U.S.Awake for Aneurysm Brain Surgery, Better Results?Does Autism Risk Reside in Cells' Energy Engines?More Evidence Contact Sports Can Affect the BrainVirtual House Calls for Speedy, Effective Parkinson's CareSeven Imaging Biomarkers Tied to Cognition in Male FightersDiabetes Drug Shows Promise Against Parkinson'sCombined MRI Might Help Predict Brain Damage in BoxersMedical Reality Catches Up to Science FictionNoninvasive Brain Test May Pinpoint Type of DementiaIn Mice, Brain Cells Discovered That Might Control AgingScans May Show Consciousness in 'Comatose' PatientsBoxers, MMA Fighters May Face Long-Term Harm to Brain: StudyFDA Panel OKs What May Soon Be First Gene Therapy Approved in U.S.Early Parkinson's May Prompt Vision ProblemsWhole-Genome Sequencing of Uncertain Clinical UtilityCould Shift Work Damage Your DNA?Gene Sequencing May Reveal Risks for Rare DiseasesRogue Genes May Cause Some ALS CasesSticky Brain 'Plaques' Implicated in Alzheimer's AgainEven Your Bones Can Get Fat, Mouse Study SuggestsDoes a Low-Fat Dairy Habit Boost Parkinson's Risk?MicroRNA Biomarker Signature Identified for Allergic AsthmaHaywire Immune Cells May Help Cause BaldnessRegion in Brain Associated With Fear of Uncertain FutureBrain Scans Spot Where Fear and Anxiety LiveGene Therapy Might Someday Mend Badly Broken BonesLife Expectancy Slighter Shorter With Parkinson's, DementiaStudy Looks at Parkinson's Effect on Life SpanBody Cooling May Help Brain After Cardiac ArrestDo You Overeat? Your Brain Wiring May Be WhyGene Mutation May Speed Alzheimer's DeclineIs This Enzyme Making You Fat?Type 2 Diabetes May Be Bad for Brain Health'Brain Age' May Help Predict When You'll DieParkinson's Disease May Originate in Gut, Study SaysBlood-Based Genome Testing Feasible for Rapid Mutation AssayBlood Test May Gauge Death Risk After Surgery
Questions and AnswersVideosLinksBook Reviews
Related Topics

Mental Disorders
Mental Health Professions
Alzheimers Disease and other Cognitive Disorders

Is This Enzyme Making You Fat?

HealthDay News
by -- Robert Preidt
Updated: May 3rd 2017

new article illustration

WEDNESDAY, May 3, 2017 (HealthDay News) -- Researchers say they've found an enzyme in mice associated with obesity and a loss of exercise capacity in midlife, suggesting that the discovery could eventually lead to new weight-loss medications.

The team at the U.S. National Heart, Lung, and Blood Institute (NHLBI) gave one group of mice a drug that inhibits the activity of the enzyme called DNA-PK. Another group of mice wasn't given the drug. Both groups were fed a high-fat diet.

The group that received the inhibitor had 40 percent less weight gain than the other group, according to the study in the journal Cell Metabolism.

The findings challenge current ideas about why people gain weight as they age, the researchers said.

"Our society attributes the weight gain and lack of exercise at midlife [approximately 30-60 years] primarily to poor lifestyle choices and lack of willpower," said study lead author Dr. Jay Chung, head of the institute's Laboratory of Obesity and Aging Research.

The researchers said the average weight gain between age 20 and 50 is about 30 pounds, even though the amount of food a person consumes generally decreases during this time.

Chung and his colleagues looked for biochemical changes in animals during midlife and found that DNA-PK increases in activity with age. Also, the researchers said the enzyme helps the conversion of nutrients to fat.

"This study shows that there is a genetic program driven by an overactive enzyme that promotes weight gain and loss of exercise capacity at midlife," Chung said in a NHLBI news release.

"Our studies indicate that DNA-PK is one of the drivers of the metabolic and fitness decline that occurs during aging, which makes staying lean and physically fit difficult and increases susceptibility to metabolic diseases like diabetes. The identification of this new mechanism is very important for improving public health," he said.

Obesity is linked with a number of chronic diseases, including type 2 diabetes and heart disease.

"The study opens the door to the development of a new type of weight-loss medication that could work by inhibiting DNA-PK activity," Chung said.

However, it's important to note that research that seems promising in animals doesn't always translate well to humans.

For now, middle-aged people fighting obesity need to focus on calorie reduction and increased exercise, the researchers recommended.

More information

The U.S. Centers for Disease Control and Prevention has more on weight.