19815 Bay Branch Rd
Andalusia, Alabama 36420
(334) 222-2525



Facebook    

 

SCAMHC is an approved Mental Health site for the National Health Service Corps Loan Repayment program.  Find out the program details and see if you qualify by visiting: http://nhsc.hrsa.gov/

SCAMHC is an Equal Opportunity Provider and Employer and maintains a Drug-Free Workplace


powered by centersite dot net
Health Sciences
Resources
Basic InformationLatest News
Genes Start Mutating Soon After Life Begins, Study FindsMore Men Than Women With Parkinson's Have Caregivers'Fountain of Youth' Gene Discovered in Secluded Amish CommunityLRRK2 Variants Linked to Lower Age at Onset of Parkinson'sKnowing Too Much About Your Genes Might Be RiskyOverlapping Surgery Appears Safe in Neurosurgical ProceduresDo I Know Ewe?Daytime Wounds May Heal Faster Than Nighttime OnesHuman vs. Animal Brainpower: More Alike Than You Might ThinkResilient Brain Connections May Help Against Alzheimer'sConcerns Surround Use of Direct-to-Consumer Genetic TestingWhen It Comes to Obesity, Genes Just Partly to BlameDoes Time of Neurosurgery Matter?Smoking Alters Genetic Relationship with Parkinson'sHealth Tip: Considering Genetic TestingDiabetes Ups Risk of MACE in Acute Coronary SyndromesScientists Spot Genes Behind Skin ColorScientists Support Genome Editing to Prevent DiseaseBrain Disconnects Spotted in Parkinson's Patients With Visual HallucinationsCoffee Doesn't Help Parkinson's Motor DisordersCan Babies Help Heart Patients?Scientists Spot Marker for CTE in Living Football PlayersNerve Stimulation Pulls Patient From 15-Year Vegetative StateWhy Your Nose May Be Key to Parkinson's RiskEvolution Not Over for HumansBrain Scans Offer Clues to Why Some Teens Pile on PoundsNew Clues to Why Yawns Are ContagiousNew Hope From Old Drugs in Fight Against Parkinson'sFirst Gene Therapy Approved in U.S.Awake for Aneurysm Brain Surgery, Better Results?Does Autism Risk Reside in Cells' Energy Engines?More Evidence Contact Sports Can Affect the BrainVirtual House Calls for Speedy, Effective Parkinson's CareSeven Imaging Biomarkers Tied to Cognition in Male FightersDiabetes Drug Shows Promise Against Parkinson'sCombined MRI Might Help Predict Brain Damage in BoxersMedical Reality Catches Up to Science FictionNoninvasive Brain Test May Pinpoint Type of DementiaIn Mice, Brain Cells Discovered That Might Control AgingScans May Show Consciousness in 'Comatose' PatientsBoxers, MMA Fighters May Face Long-Term Harm to Brain: StudyFDA Panel OKs What May Soon Be First Gene Therapy Approved in U.S.Early Parkinson's May Prompt Vision ProblemsWhole-Genome Sequencing of Uncertain Clinical UtilityCould Shift Work Damage Your DNA?Gene Sequencing May Reveal Risks for Rare DiseasesRogue Genes May Cause Some ALS CasesSticky Brain 'Plaques' Implicated in Alzheimer's AgainEven Your Bones Can Get Fat, Mouse Study SuggestsDoes a Low-Fat Dairy Habit Boost Parkinson's Risk?
Questions and AnswersVideosLinksBook Reviews
Related Topics

Mental Disorders
Mental Health Professions
Alzheimers Disease and other Cognitive Disorders

Gene Therapy Shows Promise for Aggressive Lymphoma

HealthDay News
by -- Margaret Farley Steele
Updated: Feb 28th 2017

new article illustration

TUESDAY, Feb. 28, 2017 (HealthDay News) -- An experimental gene therapy for aggressive non-Hodgkin lymphoma beat back more than a third of cancers that seemed untreatable, the therapy's developers report.

Thirty-six percent of over 100 very ill lymphoma patients appeared disease-free six months after a single treatment, according to results released by the treatment's maker, Kite Pharma of Santa Monica, Calif.

These patients had not responded to usual treatments and had no other options, Kite said Tuesday in a news release.

Overall, more than four out of five patients with the blood cancer saw their cancer reduced by more than half for at least part of the study, the company said.

"This seems extraordinary ... extremely encouraging," one cancer specialist, Dr. Roy Herbst, told the Associated Press.

But Herbst, who is chief of medical oncology at Yale Cancer Center in New Haven, Conn., said longer follow-up is needed to see if the benefit continues.

Still, he said, "This certainly is something I would want to have available." Side effects, which had been a concern, seemed manageable in this study, he said.

The therapy -- called CAR-T cell therapy -- enables the patient's own blood cells to kill the cancer cells.

Lymphoma is a general term for cancers that begin in the lymph system. The lymph system is part of the immune system, which helps the body fight disease.

Here's how the treatment works: A patient's blood is filtered so immune cells called T-cells can be altered to contain a cancer-fighting gene. The cells are returned to the patient intravenously, and the cancer-targeting cells then multiply in the patient's body.

The U.S. National Cancer Institute developed the gene approach and licensed it to Kite. Now, Kite and another pharmaceutical giant, Novartis AG, are competing to gain approval of the treatment, according to the AP.

Kite reportedly intends to seek U.S. Food and Drug Administration approval this spring and approval in Europe later this year. It could be the first gene therapy approved in the United States, the news report noted.

Although the therapy appears to benefit a significant number of patients, it is not risk-free. Researchers believe two patients died of treatment-related causes, the AP reported.

Other side effects included anemia or other blood problems that were treated, and neurological problems such as sleepiness, confusion, tremor or difficulty speaking, which typically lasted only a few days, the wire service reported.

Overall, however, the therapy seems safe, according to Dr. Steven Rosenberg, chief of surgery branch at the National Cancer Institute. He was not involved with the study.

"It's a safe treatment, certainly a lot safer than having progressive lymphoma," Rosenberg told the AP. He said he has a patient who was treated this way who is still in remission seven years later.

The cost of such treatment hasn't been reported yet, but immune system therapies tend to be very expensive.

The results are scheduled for presentation at the American Association for Cancer Research conference in April. Until published in a peer-reviewed medical journal, the data and conclusions should be considered preliminary.

More information

The U.S. National Cancer Institute has more about lymphoma.