19815 Bay Branch Rd
Andalusia, Alabama 36420
(334) 222-2523
HELPLINE: 1-877-530-0002



Facebook    

 

SCAMHC is an approved Mental Health site for the National Health Service Corps Loan Repayment program.  Find out the program details and see if you qualify by visiting: http://nhsc.hrsa.gov/

SCAMHC is an Equal Opportunity Provider and Employer and maintains a Drug-Free Workplace

 

 

 

 


powered by centersite dot net
Pain Management
Resources
Basic InformationLatest News
Many Doctors Refusing Care of People Prescribed OpioidsFewer Opioid Painkillers Can Still Control Surgery PainFDA Grants First Approvals for Generic Versions of LyricaMore Than 5 Million U.S. Cancer Survivors Deal With Chronic PainThe Safer Way to Ease Post-Surgical PainOpioids Prescribed in Hospital Often Tied to Long-Term UseDentists Prescribe Antibiotics Far Too Often: StudyMany Patients Don't Need Opioids After SurgeryU.S. Dentists Prescribe 37 Times More Opioids Than in England: StudyCould Hypnotherapy Be Alternative to Opioids for Pain?Don't Suddenly Stop Taking a Prescribed Opioid, FDA WarnsInsurers' Denials of Opioid Coverage Spurs CDC to Clarify GuidelinesAHA News: Opioid Meds Pose Danger to Kidney Disease PatientsMedical Pot: An Elixir for the Elderly?Upbeat Attitude May Be a Pain FighterWhy Do More and More Americans Use Medical Marijuana?Little Evidence Pain Creams Work'Mindfulness' Might Help Some Conquer Chronic PainMany Parents Conflicted About Opioids for Their Teens' PainOpioid Prescriptions Almost Twice as Likely for Rural vs. Urban AmericansOpioid Use in Pregnancy Tied to Severe Birth DefectsMore Americans Mixing Opioids With SedativesOpioids May Help Chronic Pain, But Not MuchPhysical Therapy Can Help You Avoid Opioids When Joint Pain StrikesNagging Low Back Pain? Try MindfulnessOpioids Plus Other Drugs a Deadly Mix for Heavy UsersHealth Tip: Manage Pain With OpioidsDoctors More Cautious Now When Prescribing Opioids to KidsEven Wisdom Tooth Removal May Spur Opioid AddictionOnly a Quarter of Opioid Painkillers Taken After Most SurgeriesOpioid Use May Sometimes Trigger A-FibFDA Approves Powerful New Opioid Despite CriticismsA New Challenger to Medical Marijuana?New Nerve Stimulation Technique Might Relieve Back PainDespite Opioid Crisis, Most Patients Want the Drugs for Post-Op Pain1 in 12 Americans Lives With Debilitating Chronic PainMindfulness May Be a Buffer Against PainCould a Placebo Pill Help Ease Your Back Pain?Chronic Pain May Drive Some to SuicideMonkey Trials Raise Hope for Non-Addictive Opioid AlternativeGovernment Rules Aimed at Curbing Opioid Prescriptions May Have Backfired
Questions and AnswersVideosLinksBook Reviews
Related Topics

Depression: Depression & Related Conditions
Mental Disorders
Medications

Monkey Trials Raise Hope for Non-Addictive Opioid Alternative

HealthDay News
by -- Robert Preidt
Updated: Aug 30th 2018

new article illustration

THURSDAY, Aug. 30, 2018 (HealthDay News) -- The ongoing opioid addiction crisis means the search for powerful but non-addictive painkillers is more urgent than ever before. Now, a team of scientists says it may be nearing that goal.

Research in monkeys suggests that an experimental painkiller -- called AT-121 -- is not only very effective in easing pain, but it may also blunt the addictive effects of opioids.

AT-121 provided the same level of pain relief as a typical opioid, but at a 100-times lower dose than morphine, according to the research team from Wake Forest Baptist Medical Center, in Winston-Salem, N.C.

"In our study, we found AT-121 to be safe and non-addictive, as well as an effective pain medication," said Mei-Chuan Ko, a professor of physiology and pharmacology at the hospital.

"In addition, this compound also was effective at blocking abuse potential of prescription opioids, much like buprenorphine does for heroin, so we hope it could be used to treat [both] pain and opioid abuse," Ko added in a Wake Forest news release.

The research showed that -- in monkeys, at least -- AT-121 suppressed the addictive potential of oxycodone (Oxycontin), a commonly abused opioid prescription drug.

In the experiments, monkeys were able to "self-administer" potentially addictive drugs such as cocaine or oxycodone, but when given AT-121, they were no more likely to do so than when they'd received simple saline solutions.

According to Ko's team, this suggests that AT-121 lacks the addictive potential of typical opioids.

And unlike typical opioids, withdrawal symptoms weren't observed when the monkeys ceased using AT-121 after three days, the researchers said.

AT-121 also seemed to ease pain without some of the typical side effects of opioids, such as itch, motor impairment, respiratory and other issues.

Of course, trials conducted in animals sometimes fail to pan out in people. But Ko noted that monkeys are a very close model to humans.

"The fact that this data was in non-human primates, a closely related species to humans," suggests that the findings have a good chance of being replicated in clinical trials in people, he said.

Still, further research -- including safety studies -- is needed before applying to the U.S. Food and Drug Administration for approval to conduct those clinical trials, Ko said.

The study was published Aug. 29 in the journal Science Translational Medicine.

More information

The U.S. National Institute on Drug Abuse has more about prescription opioids.